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Prisco's Week 1 NFL picks: Rams edge 49ers, Bills end skid vs. Texans - CBS Sports
Pete Prisco reveals all of his season-opening picks, including a healthy dose of Patrick Mahomes in a win over the Broncos
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CBS Sports
10 Sep 2026 · 1 min read
It's NFL picks time again, which means Week 1 torture. Figuring out Week 1 picks is as complicated as it gets. We have no idea who will be good and who will be bad. How will new coaches impact teams…